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PDRN (polydeoxyribonucleotide) is one of the most-talked-about Korean dermatology ingredients, used in the Rejuran clinic injection for regenerative treatment. Topical PDRN skincare has become a major category, with medicube's PDRN Pink Tension Up Mask bringing the ingredient into sheet mask format. The "Pink" in the name refers to the signature color of the brand's PDRN line; "Tension Up" refers to the firmness-boosting effect. At $53 for 4 masks ($13.25 per mask), these are premium-priced sheet masks.
PDRN sheet masks are positioned for post-procedure recovery (post-laser, post-peel), pre-event skin prep, and as intensive weekly treatments for mature skin. The 34g mask weight indicates generous essence delivery; these are ampoule-tier sheet masks, not casual daily ones.
PDRN (from salmon sperm DNA or equivalent bioengineered sources) binds adenosine receptors in skin cells, signaling regeneration, collagen production, and inflammation reduction. In sheet mask format, the prolonged 20-minute contact time allows significant active delivery. One session produces immediate firmness and glow; a 4-mask cycle (one mask every 2 to 3 days) supports visible skin recovery and anti-aging over 2 weeks.
Apply to clean, toned skin. Smooth out air bubbles. Leave on 20 to 30 minutes. Remove and pat remaining essence into skin. Don't rinse. Follow with cream. For post-procedure recovery, use one mask every 2 to 3 days for 2 weeks. For anti-aging maintenance, 1 mask per week.
The REJURAN serum is a daily-use topical ampoule with c-PDRN at high concentration. The medicube sheet mask is an intensive weekly treatment with PDRN. Different formats for different uses. Many users combine: daily REJURAN serum routine plus weekly PDRN sheet mask for extra boost.
PDRN is from salmon, not shellfish. Salmon-derived PDRN is considered safe for most users. If you have a specific salmon allergy, avoid. Shellfish allergies are not typically an issue.
No, PDRN is salmon-derived. For vegan users, this product is not suitable.
Immediate glow: post-session. Firmness improvements: visible after 2 to 3 sessions. Post-procedure recovery acceleration: noticeable within the 2-week cycle.
Skip other actives on mask days. PDRN is powerful enough to stand alone; stacking with retinol or acids on the same day can over-tax the skin.
Pair with REJURAN Healer Turnover Synergy Cream for ongoing PDRN routine, or REJURAN Healer Turnover Ampoule. Browse the medicube collection, PDRN skincare.
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